General Information

  • ID:  hor005540
  • Uniprot ID:  P91963
  • Protein name:  PDH precursor-related peptide
  • Gene name:  PDH1
  • Organism:  Penaeus vannamei (Whiteleg shrimp) (Litopenaeus vannamei)
  • Family:  Arthropod PDH family
  • Source:  animal
  • Expression:  Eyestalk.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Penaeus (genus), Penaeidae (family), Penaeoidea (superfamily), Dendrobranchiata (suborder), Decapoda (order), Eucarida (superorder), Eumalacostraca (subclass), Malacostraca (class), Multicrustacea (superclass), Crustacea (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction; GO:0007268 chemical synaptic transmission; GO:0009416 response to light stimulus
  • GO CC:  GO:0005576 extracellular region; GO:0045202 synapse

Sequence Information

  • Sequence:  QEDLKYFEREVVAELAAQILRVAQGPSAFVAGPH
  • Length:  34(23-56)
  • Propeptide:  MRSAVVVALLVMVAMSLQLTAAQEDLKYFEREVVAELAAQILRVAQGPSAFVAGPHKRNSELINSLLGIPKVMNDAGRR
  • Signal peptide:  MRSAVVVALLVMVAMSLQLTAA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  The pigment-dispersing hormone causes the migration of the distal retinal pigment into the proximal end of the pigment chromatophore cells and thus decreases the amount of light entering the retinulas. May also function as a neurotransmitter and/or neurom
  • Mechanism:  The function of PDH precursor-related peptide is unknown. The sequence is not well-conserved among different species and that might be an indication that it is inactive.
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P91963-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor005540_AF2.pdbhor005540_ESM.pdb

Physical Information

Mass: 432905 Formula: C169H264N46O50
Absent amino acids: CMNTW Common amino acids: A
pI: 4.7 Basic residues: 4
Polar residues: 4 Hydrophobic residues: 16
Hydrophobicity: -3.24 Boman Index: -4163
Half-Life: 0.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 97.65
Instability Index: 3553.24 Extinction Coefficient cystines: 1490
Absorbance 280nm: 45.15

Literature

  • PubMed ID:  8630031
  • Title:  Molecular cloning of the precursors of pigment-dispersing hormone in Crustaceans.